UNCOVER THE HIDDEN DANGERS
OF IRON DEFICIENCY IN YOUR PATIENTS
Iron deficiency (ID) in heart failure (HF) is often underdiagnosed, undertreated, and one of the most common comorbidities1-3
of all patients with
HF have iron deficiency.4
of patients with
New York Heart Association (NYHA)
class II or III had iron deficiency
or iron deficiency anemia (IDA).5
2022 AHA/ACC/HFSA GUIDELINES SPOTLIGHT
Routine baseline assessment of all patients with HF should include an evaluation for iron deficiency and anemia, class 1 (strong) recommendations.6,7
Iron deficiency in patients with heart failure can be severe and may increase the risk of worsening outcomes8
Iron deficiency in HF impacts:
Quality of life (QoL)8
Exercise capacity8
Clinical outcomes8
Patients with HF report that iron deficiency significantly impacts their activities of daily living (ADL) by reducing their ability to do housework, vacation, rest during the day, and walk or climb stairs.9
THE IMPACT OF TREATING ID CAN BE OBVIOUS
Iron deficiency in HF has been associated with a two-fold increase in the risk of hospitalization and a 40%-60% increase in the risk of mortality.8
See why it’s important to evaluate patients with heart failure for iron deficiency in this illustrative video6
References: 1. López-Vilella R, Lozano-Edo S, Arenas Martin P, et al. Impact of intravenous ferric carboxymaltose on heart failure with preserved and reduced ejection fraction. ESC Heart Fail. 2022;9(1):133-145. doi:10.1002/ehf2.13753 2. Mistry R, Hosoya H, Kohut A, Ford P. Iron deficiency in heart failure, an underdiagnosed and undertreated condition during hospitalization. Ann Hematol. 2019;98(10):2293-2297. doi:10.1007/s00277-019-03777-w
3. Becher PM, Schrage B, Benson L, et al. Phenotyping heart failure patients for iron deficiency and use of intravenous iron therapy: data from the Swedish Heart Failure Registry. Eur J Heart Fail. 2021;23(11):1844-1854. doi:10.1002/ejhf.2338 4. Ebner N, von Haehling S. Why is iron deficiency recognised as an important comorbidity in heart failure? Card Fail Rev. 2019;5(3):173-175. doi:10.15420/cfr.2019.9.2 5. Klip IT, Comin-Colet J, Voors AA, et al. Iron deficiency in chronic heart failure: an international pooled analysis. Am Heart J. 2013;165(4):575-582.e3. doi:10.1016/j.ahj.2013.01.017 6. Heidenreich PA, Bozkurt B, Aguilar D, et al. 2022 AHA/ACC/HFSA guideline for the management of heart failure: a report of the American College of Cardiology/American Heart Association Joint Committee on Clinical Practice Guidelines. J Am Coll Cardiol. 2022;79(17):e263-e421. doi.org/10.1016/j.jacc.2021.12.012 7. Pocket Guide derived from Heidenreich PA, Bozkurt B, Aguilar D, et al. 2022 AHA/ACC/HFSA guideline for the management of heart failure: a report of the American College of Cardiology/American Heart Association Joint Committee on Clinical Practice Guidelines. J Am Coll Cardiol. 2022;79(17):e263-e421. doi.org/10.1016/j.jacc.2021.12.012 8. Lam CSP, Doehner W, Comin-Colet J; IRON CORE Group. Iron deficiency in chronic heart failure: case-based practical guidance. ESC Heart Fail. 2018;5(5):764-771. doi:10.1002/ehf2.12333 9. Comín-Colet J, Enjuanes C, González G, et al. Iron deficiency is a key determinant of health-related quality of life in patients with chronic heart failure regardless of anaemia status. Eur J Heart Fail. 2013;15(10):1164-1172. doi:10.1093/eurjhf/hft083